Alternatively, you can download the file locally and open with any standalone pdf reader. Pseudothrombocytopenia caused by platelet agglutinins that are reactive in blood anticoagulated with chelating agents. Abstractplatelet satellitism ps is a rare phenomenon observed in blood smears obtained from blood. Edtadependent pseudothrombocytopenia differentiation from true thrombocytopenia. An accurate platelet count can be obtained with a manual count using phase. Edtadependent pseudothrombocytopenia is a rare phenomenon i.
Blood clotting is impaired in thrombocytopenia, resulting in a tendency of the mucous membranes to bleed, as well as in hemorrhaging and the appearance of petechiae in the internal organs. It is often discovered incidentally when it is often discovered incidentally when obtaining a complete blood count. Spuriously low electronic platelet counts were obtained on blood collected in edta from six patients. This article is within the scope of wikiproject medicine, which recommends that medicinerelated articles follow the manual of style for medicinerelated articles and that biomedical information in any article use highquality medical sources.
Thrombocytopenic disorders can be life threatening, with increased bleeding or even thrombotic risk, depending on the underlying cause, and the clinical context eg, an acutely ill, pregnant, or ambulatory patient helps to determine which tests should be ordered and with what urgency. Once identified in the laboratory, a low platelet count requires the use of some methods to establish the correct diagnosis. Pseudothrombocytopenia definition of pseudothrombocytopenia. Pseudothrombocytopenia american society of hematology. Thrombocytopenia is a condition that causes low levels of platelets, the cells that help your blood clot. The phenomenon occurs when the anticoagulant used while testing the blood sample causes clumping of platelets which mimics a low platelet count. Pseudothrombocytopenia with multiple anticoagulant sample. The patient was diagnosed with pseudothrombocytopenia and no further treatment or blood work was required. Pseudothrombocytopenia in cardiac surgical practice. Effective prevention of pseudothrombocytopenia in feline.
In july 1982, a 62yearold man was hospitalized for thrombocytopenia. Multianticoagulant and edta dependent pseudothrombocytopenia. Joann luy satellite laboratory services redwood city, ca. The knowledge of pseudothrombocytopenia ptcp is important for the accuracy of a clinical assessment and for avoiding unnecessary. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience.
Thrombocytopenia article about thrombocytopenia by the free. You can manage this and all other alerts in my account. Platelet satellitism and platelet clumping can cause pseudo thrombocytopenia. Platelet satellitism was first reported in the early 1960s. If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a pdf plugin installed and enabled in your browser. Apr 21, 2011 view large download ppt a 57yearold retired farmer with no personal or family history of bleeding was found to have thrombocytopenia on routine blood work. Occurrence and clinical significance of pseudothrombocytopenia. Pseudothrombocytopenia or spurious thrombocytopenia is an invitro sampling problem which may mislead the diagnosis towards the more critical condition of thrombocytopenia. Ethylenediaminetetraacetic acid edtainduced thrombocytopenia. Pseudothrombocytopenia an overview sciencedirect topics. Full blood count was performed in a sample of heparinanticoagulated blood, which confirmed normal platelet count and distribution as shown in fig. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Recognition and prevention of pseudothrombocytopenia and. After completing this course the participant will be able to.
Explain how to determine the platelet count when the count is above the upper reportable range of the analyzer. Pseudothrombocytopenia occurs using the edta and other anticoagulants, in the process of determining the platelet count on the ha. Edtadependent pseudothrombocytopenia edtaptcp is a common laboratory phenomenon with a prevalence ranging from 0. What percentage of specimens with pseudothrombocytopenia caused by edtadependent platelet satellitosis is resolved by collecting in a sodium citrate tube. The incidence of pseudothrombocytopenia in automatic blood.
A case of pseudothrombocytopenia in an obstetric patient you will receive an email whenever this article is corrected, updated, or cited in the literature. Pseudo thrombocytopenia ptp is a phenomenon of falsely low platelet counts obtained on hematology analyzers. In this article we reported a case of a 23yearold female with edtainduced thrombocytopenia and a. A peripheral blood film showed clumping of platelets shown. Thrombocytopenia may also result from disturbance of platelet formation in the bone marrow in leukemia or aplastic anemia, and from ionizing radiation. Pseudothrombocytopenia is the result of platelet clumping in vitro, which may be. The clinical features, bleeding complications and major clinical outcomes of patients with pseudothrombocytopenia and those with thrombocytopenia were. Learn more about the causes, symptoms, and treatment of thrombocytopenia. Jun 21, 2019 idiopatik trombositopenia pdf woc idiopatik trombositopenia purpura free download as word doc.
A repeat cbc was done in sodium citrate and the platelet count was normal. To download the pdf, click the download link below. Michael evans developed the onepager concept to provide clinicians with useful clinical information on primary care topics. Edtadependent pseudothrombocytopenia ptcp is the phenomenon of a spurious low platelet count due to edtainduced aggregation of platelets. It is a rare condition that occurs when an igg antibody forms in the presence of edta, the anticoagulant that is used for the collection of hematology blood specimens. Alternatively, you can also download the pdf file directly to your computer, from where it can be opened using a pdf reader. Pseudothrombocytopenia, blood, volume 117, issue 16, 21 april 2011, pages 4168. Whats that platelet counta case of pseudothrombocytopenia. In adults, thrombocytopenia is a platelet count of less than 150. Edtaptcp is often overlooked because blood smears are not. Evaluation of the peripheral blood smear ahmed shorafa, md 542015 2. Despite its harmlessness, edtaptcp frequently leads to timeconsuming, costly and even invasive diagnostic investigations. We recently saw a patient with still another type of pseudothrombocytopenia. Pseudothrombocytopenia and mexiletine annals of internal.
Pseudothrombocytopenia was a possible explanation as the patient did not manifest any bleeding tendency. Dear joann luy, ive never seen data expressing a percentage, perhaps some of our participants have an answer. We have observed a hitherto unknown association between mexiletine and pseudothrombocytopenia, in which antibodies in patients sera 3 react with platelets anticoagulated with edetic acid or other agents 4, 5 causing agglutination and spuriously low platelet counts. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader. Ppt thrombocytopenia powerpoint presentation free to. Pdf pseudothrombocytopenia due to platelet clumping. Pseudothrombocytopenia ptcp is an in vitro phenomenon of platelet aggregation that results in spurious reporting of a low platelet count by automatic cell counters, which are typically edta dependent. If the inline pdf is not rendering correctly, you can download the pdf file here.
An acute drop in the platelet count by 50%, even if it remains in the normal range. Edtadependent pseudothrombocytopenia sciencedirect. The incidence of pseudothrombocytopenia in automatic blood analyzers. Since the failure to recognize edtadependent ptcp may result in incorrect diagnosis and inappropriate treatment, the recognition of this phenomenon is very important. It can be readily recognized by inspecting conventional blood smears or the white blood cell histograms generated by modern blood cell counters. The original blood sample used ethylenediaminetetraacetic acid edta as an anticoagulant. Pseudothrombocytopenia is the result of platelet clumping in vitro, which may be induced either by a antibodymediated agglutination, the most important causes of which are ethylenediaminetetraacetic acid edtadependent agglutination1 and platelet satellitism,2 or b aggregation secondary to platelet activation resulting from improper blood sampling techniques. He had a history of type 2 diabetes, hypertension, hyperlipidemia, and osteoarthritis. Pseudothrombocytopenia induced by incubation at 37. Pseudothrombocytopenia blood american society of hematology. Thrombocytopenia is defined as a platelet count of less than 150. Unrecognized anticoagulantinduced platelet plt aggregation, leading to pseudothrombocytopenia and concomitant pseudoleukocytosis, can have serious clinical consequences. The correct use and concentration of anticoagulant is mandatory to avoid spurious results, which can influence clinical decision. The preanalytical phase is particularly important in haematology, where counts of particles and cells are performed in whole anticoagulated blood.
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